>sp|B2RZ87|MADL2_RAT Myeloid-associated differentiation marker-like protein >tr|D3ZJ19|D3ZJ19_RAT Protein Satb2 OS=Rattus norvegicus GN=Satb2

SATB2 as an Immunohistochemical Marker for Colorectal Adenocarcinoma: A Concise Review of Benefits and Pitfalls. SATB2 is part of the family of matrix attachment region-binding transcription factors, and has developmental roles in craniofacial, neural, and osteoblastic differentiation.

SATB2 is a new immunohistochemical marker with a few studies showing that it is specifically expressed in a large majority of colorectal adenocarcinomas. We assessed SATB2 along with CDX2 in patient material with metastasis in order to determine whether the primary site could be identified as 'colon-rectum'. SATB2 is a biomarker for colorectal cancer, 85% of all CRC patients are positive for SATB2 and other cancer types rarely display SATB2 expression SATB2 in combination with cytokeratin 20 identifies over 95% of all colorectal carcinomas (Am J Surg Pathol 2011;35:937) The Role of SATB2 as a Diagnostic Marker of Sinonasal Intestinal-type Adenocarcinoma. Skalova A (1) (2), Sar A (3), Laco J (4), Metelkova A (5), Miesbauerova M (1), Steiner P (1) (6), Švajdler M (1) (2), Michal M (1). SATB2 has gained interest as a relatively specific marker of colorectal differentiation, with potential applications including determining origin of adenocarcinomas of unknown primary and distinguishing primary ovarian mucinous adenocarcinomas from colorectal metastases.

Satb2 marker

SATB2 is part of the family of matrix attachment region–binding transcription factors, and has developmental roles in craniofacial, neural, and osteoblastic differentiation. The invention provides new methods, means and uses in connection with detection, characterization and prognosis of colo-rectal cancer, via the identification of the SATB2 protein as a marker for this 2021-03-07 · SATB2 is a marker of osteoblastic differentiation in benign and malignant mesenchymal tumours. These findings indicate that SATB2 activates UPF3B expression through binding to its promoter. SATB2 might involve in the development and progression of laryngeal squamous cell carcinoma. In Satb2 mutant animals, the expression of several Layer 5 differentiation markers was reduced compared with wildtype controls, indicating an incomplete differentiation of Satb2-deficient SCPNs. These molecular changes were accompanied by a failure of the CST to extend past the cerebral peduncle and into the spinal cord.

In this study, we validated the prognostic ability of SATB2 expression in a large, prospective CRC cohort.

IHC for SATB2 can be used as a marker to determine the origin of a cancer of unknown primary site (CUP). Publications have reported SATB2 in combination with CDX2 to be highly valuable to identify colorectal carcinomas with a reported analytical sensitivity typically in the range of 85-95%.

2008-02-07 · To determine whether the expression of DL genes was also affected in Satb2 −/− mice, we performed ISH and IHC with several deep-layer markers. ISH of the layer 5 marker Er81 ( Figures 7 D and 7H) and layer 4 marker RoRβ (data not shown) showed that their expression domains were not altered in E15.5 and E17.5 mutant brains; Fezf2 expression was also not affected by the Satb2 mutation (data not shown). Cortical layer markers are useful tools for studying the development, functional neuroanatomy and pathology of the cerebral cortex. The cerebral cortex is organized into six layers of both morphologically and functionally divergent neurons.

SATB2 induced malignant transformation and these transformed cells gained the characteristics of CSCs by expressing stem cell markers (CD44, CD133, LGR5 and DCLK1) and transcription factors (c-Myc

SATB2 is a biomarker for colorectal cancer, 85% of all CRC patients are positive for SATB2 and other cancer types rarely display SATB2 expression SATB2 in combination with cytokeratin 20 identifies over 95% of all colorectal carcinomas (Am J Surg Pathol 2011;35:937) SATB2 has been implicated as causative in the cleft or high palate of individuals with 2q32q33 microdeletion syndrome. SATB2 was found to be disrupted in two unrelated cases with de novo apparently balanced chromosome translocations associated with cleft palate and Pierre Robin sequence. SATB2 was recently reported to have high sensitivity and specificity as a marker of colorectal adenocarcinoma. However, Like CDX2, SATB2 is also expressed in a subset of upper gastrointestinal adenocarcinomas (ADCAs) but rarely expressed in SATB2 is more specific than CDX2 when used to rule SATB2 is a new immunohistochemical marker with a few studies showing that it is specifically expressed in a large majority of colorectal adenocarcinomas. We assessed SATB2 along with CDX2 in patient material with metastasis in order to determine whether the primary site could be identified as ‘colon‐rectum’. SATB2 is a new immunohistochemical marker with a few studies showing that it is specifically expressed in a large majority of colorectal adenocarcinomas. We assessed SATB2 along with CDX2 in patient material with metastasis in order to determine whether the primary site could be identified as ‘colon‐rectum’.

View mouse Satb2 Chr1:56793981-56978650 with: phenotypes, sequences, polymorphisms, Satb2 interacts with 438 markers (Mir1a-1, Mir1a-2, Mir1b, . In addition, because SATB2 is also a highly sensitive and specific marker for colorectal adenocarcinomas, it could also serve as a complementary marker in the Special AT-rich sequence-binding protein 2 (SATB2) is a recently described marker that functions as a nuclear matrix-associated transcription factor. It has been SATB2 : Special AT-rich sequence binding protein 2 (SATB2) is a SATB2, when used in combination with the marker Keratin 20, may identify more than 95 % 25 Jun 2019 This study assesses the addition of a novel marker SATB2, to improve the diagnostic algorithm. A test cohort included 155 ovarian mucinous 26 Nov 2019 CDX2 is the most sensitive marker for CRC and AMN, whereas SATB2 has better specificity. Introduction.
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Inhibition of SATB2 in CSCs suppresses cell proliferation, colony and spheroid formation in suspension, and EMT characteristics. SATB2 is a marker of osteoblastic differentiation in benign and malignant mesenchymal tumours.

Although SATB2 is not specific for osteosarcoma, it has the potential to be a useful adjunct in some settings, particularly in the distinction between hyalinized collagen and osteoid. SATB2 is a sensitive marker for lower gastrointestinal well-differentiated neuroendocrine tumors. Special AT-rich sequence binding protein-2 (SATB2) is selectively expressed in the lower gastrointestinal tract mucosa and has been identified as a sensitive marker for colorectal adenocarcinomas.
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SATB2 is a new immunohistochemical marker with a few studies showing that it is specifically expressed in a large majority of colorectal adenocarcinomas. We assessed SATB2 along with CDX2 in patient material with metastasis in order to determine whether the …

28 Feb 2012 In the superficial layers of the CP, Satb2-positive cells were negative for the deep -layer marker Ctip2 in the WT (Fig. 2 D and E) (8), whereas in 29 Nov 2016 The genome-organizer Satb2 has a key role in memory formation by marker Wfs1 (Figure 1E) and the cortical layer markers Cux1, Ctip2, 15 Jun 2015 Our results indicate that SATB2 is a sensitive marker for hindgut well- differentiated neuroendocrine tumors though it is not entirely specific. 15 Jun 2015 was to investigate the expression of SATB2 in well-differentiated neuroendocrine tumors to explore its potential as a diagnostic marker for 17 Jan 2014 17 and SATB-2 and other markers in medullary carcinomas of the large cy.27 Therefore, SATB2 is a potential marker for identifying a.

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24 Apr 2020 expression of the glutamatergic neuronal marker Satb2 in the mediobasal SATB2-positive cells in female mHFD offspring VMN, compared to

These findings indicate that SATB2 activates UPF3B expression through binding to its promoter. SATB2 might involve in the development and progression of laryngeal squamous cell carcinoma. In Satb2 mutant animals, the expression of several Layer 5 differentiation markers was reduced compared with wildtype controls, indicating an incomplete differentiation of Satb2-deficient SCPNs.